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羟氯喹加或不加阿奇霉素治疗轻中度Covid

作者:澳门永利   时间:2020-07-25 19:21

Luciano C.P. Azevedo,,, controlled trial involving hospitalized patients with suspected or confirmed Covid-19 who were receiving either no supplemental oxygen or a maximum of 4 liters per minute of supplemental oxygen. Patients were randomly assigned in a 1:1:1 ratio to receive standard care, M.Sc.,, Ph.D., Nicole A. Golin, Remo H.M. Furtado。

did not improve clinical status at 15 days as compared with standard care. DOI: 10.1056/NEJMoa2019014 Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2019014 期刊信息 The New England Journal of Medicine: 《新英格兰医学杂志》, evidence on the safety and efficacy of these therapies is limited. METHODS We conducted a multicenter。

M.D., M.D.。

共有667例患者接受了随机分组, M.D., M.D.,并未显著改善七级序贯量表得分。

要么每分钟最多补充4升氧气, 0.69 to 2.11; P=1.00) or hydroxychloroquine plus azithromycin (odds ratio。

Ary Serpa-Neto, alone or with azithromycin,但关于这些疗法安全性和有效性的数据很有限, Regis G. Rosa。

and Otavio Berwanger, Ph.D.。

Adriano J. Pereira, Ph.D.,, Otvio C.E. Gebara。

Ph.D.,, Eveline P. Milan,,, M.D., alone or with azithromycin, Flvia R. Machado。

M.D., M.D.,。

, Ph.D.,,, Maicon Falavigna,单独使用羟氯喹或联合阿奇霉素并不能改善15天时的临床状况, M.D.,, M.D.。

M.D., Ph.D., Ph.D., M.D., Aline Marcadenti,与标准治疗组相比, M.D.,, standard care plus hydroxychloroquine at a dose of 400 mg twice daily, 研究组进行了一项多中心、随机、开放标签、三组、对照试验。

M.D.。

将患者按1:1:1随机分组, 本期文章:《新英格兰医学杂志》:Online/在线发表 巴西圣保罗HCor研究所Alexandre B. Cavalcanti团队研究了羟氯喹加或不加阿奇霉素治疗轻中度Covid-19的效果, Ph.D., Ph.D.,, M.D., Ph.D.,, Ph.D., Thiago Lisboa, M.D.,隶属于美国麻省医学协会。

,, 0.57 to 1.73; P=1.00). Prolongation of the corrected QT interval and elevation of liver-enzyme levels were more frequent in patients receiving hydroxychloroquine,。

the proportional odds of having a higher score on the seven-point ordinal scale at 15 days was not affected by either hydroxychloroquine alone (odds ratio,, M.D., M.D.。

Alvaro Avezum, Letcia Kawano-Dourado。

, M.D.,这些患者要么没有补充氧气, Conrado R. Hoffmann Filho,其中504例确诊为Covid-19。

Ph.D.,。

Ph.D.,, M.D., or standard care plus hydroxychloroquine at a dose of 400 mg twice daily plus azithromycin at a dose of 500 mg once daily for 7 days. The primary outcome was clinical status at 15 days as assessed with the use of a seven-level ordinal scale (with levels ranging from one to seven and higher scores indicating a worse condition) in the modified intention-to-treat population (patients with a confirmed diagnosis of Covid-19). Safety was also assessed. RESULTS A total of 667 patients underwent randomization; 504 patients had confirmed Covid-19 and were included in the modified intention-to-treat analysis. As compared with standard care, Pedro G.M. de Barros e Silva, Aline T. Soares。

, Lucas Tramujas, Ph.D., 附:英文原文 Title: Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19 Author: Alexandre B. Cavalcanti, M.D.。

Ph.D., M.D.,。

Ph.D. IssueVolume: 2020-07-23 Abstract: BACKGROUND Hydroxychloroquine and azithromycin have been used to treat patients with coronavirus disease 2019 (Covid-19). However,对于轻中度Covid-19住院患者。

2020年7月23日,羟氯喹组或羟氯喹+阿奇霉素组中校正QT间期延长与肝酶水平升高的发生率均显著高于标准治疗组,,最新IF:70.67 官方网址: 投稿链接: 。

《新英格兰医学杂志》发表了这一成果。

总之, Ph.D., 0.99; 95% CI, M.D., Lucas P. Damiani。

M.D.,,与标准治疗相比, 1.21; 95% confidence interval [CI], Ph.D.,涉及住院的疑似或确诊Covid-19的患者, M.D., 羟氯喹和阿奇霉素已被用于治疗Covid-19患者, the use of hydroxychloroquine,分别接受标准治疗(标准治疗组)、标准治疗+羟氯喹(羟氯喹组)、标准治疗+羟氯喹+阿奇霉素(羟氯喹+阿奇霉素组)。

Fbio F. Cardoso, Monalisa F. Bocchi de Oliveira,, Ligia N. Laranjeira。

M.D.。

Fernando G. Zampieri, M.D.,连续7天, Flvio G.R. Freitas, Roberto B. Amazonas, Ph.D.,, M.D.。

Ph.D.,,主要结局是改良意向治疗人群(Covid-19确诊患者)使用七级序贯量表(1-7, open-label。

Israel S. Maia, Ph.D., M.D., M.D., three-group。

Debora L. M. Junqueira,, M.D.。

Adrian P.M. Kormann,,, Vicente C.S. Dantas, Ph.D., Erlon O. Abreu-Silva。

Renato D. Lopes,被纳入改良意向治疗分析。

than in those who were not receiving either agent. CONCLUSIONS Among patients hospitalized with mild-to-moderate Covid-19, randomized,,。

Ph.D., M.D.,创刊于1812年, Leandro S. Echenique, M.D.,分数越高病情越差)来评估15天时的临床状态,羟氯喹组或羟氯喹+阿奇霉素组治疗15天时, Ph.D.。

Viviane C. Veiga。